Patients experiencing symptoms of Posttraumatic Stress Disorder (PTSD) may have frequent or infrequent contact with primary care (PC) due to over or under reliance on PC which may be moderated by the patient’s level of trust in their healthcare team. This can lead to misinterpretation of the intentions of others and could cause reactions such as defensiveness or hostility, which could increase interpersonal conflict, particularly with their PC team. Symptoms of PTSD have also been related patient and provider difficulties with chronic disease management, health behavior change, and the management of other psychiatric conditions. Therefore, it is imperative to address PTSD in PC with targeted, evidence-based approaches that are appropriate for the context of PC, especially for marginalized and historically excluded groups. This presentation will discuss the impact of PTSD and Posttraumatic Stress Symptoms (PTSS) on PC as well as present evidence-informed, exposure-based approaches for addressing PTSD and PTSS in PC. Additionally, approaches for addressing ethno-racial trauma in PC will also be discussed.